International Review of Ophthalmology

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Role of CRISPR/Cas9 system in pathogensis of lens-related diseases

He Hailong1, Zhou Chunyuan2, Chang Di1, Wang Jinda1, Wan Xiuhua1   

  1. 1Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China; 2Department of Ophthalmology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
  • Received:2020-01-06 Online:2020-02-22 Published:2020-02-27
  • Contact: Wan Xiuhua，Email：xiuhuawan@163.com E-mail:xiuhuawan@163.com
  • Supported by:
    Fund of Work Committee for Women and Children of China State Department(2014108); Beijing Institute of Ophthalmology Breakthrough Project(201910)

Abstract: The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system is a new type of genome editing technology, which has the advantages of high gene knockout efficiency, accurate location, easy operation, short test cycle, low cost and so on. The emergence of CRISPR/Cas9 system provides a new idea for the diagnosis and treatment of ophthalmopathy, especially lens-related diseases, and plays a certain role in the research and treatment of the pathogenesis and treatment of congenital cataract, the construction of congenital cataract model, the identification of mutated gene loci of lens-related diseases, and the prevention and treatment of posterior capsular opacification.